Search Whole Database

Search for Targets:
Examples: EGFR; Vascular endothelial growth factor; Peramivir; Renal cell carcinoma ...
Search for Drugs:
Examples: Cabozantinib; Ebola virus infection; Oseltamivir ...
Search Drugs and Targets by Disease or ICD Identifier:
Examples: Influenza; Alzheimer; ICD9: 331; ICD10: G30 ...
Search for Biomarkers:
Examples: Breast cancer; p53; ICD9: 331; ICD10: G30 ...
Search for Drug Scaffolds:
How to Cite Our Database:

Y. H. Li, C. Y. Yu, X. X. Li, P. Zhang, J. Tang, Q. Yang, T. Fu, X. Zhang, X. Cui, G. Tu, Y. Zhang, S. Li, F. Yang, Q. Sun, C. Qin, X. Zeng, Z. Chen, Y. Z. Chen, and F. Zhu. Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics. Nucleic Acids Research. 46(D1): D1121–D1127, 2018. PMID: 29140520

List of Publications citing TTD (till Aug 12th, 2017)

Statistics of Therapeutic Target Database (TTD) Update 2018
  • 2,000 drug resistance mutations in 40 successful, 34 clinical trial, 9 research targets and 104 drug resistance genes associated with 128 approved, 56 clinical trial and 44 research drugs targeting 63 diseases (49 targets of 61 drugs with patient prevalence data)
  • Differential expression profiles and downloadable data of 309 successful and 449 clinical trial targets in 12,615 patients of 70 diseases
  • Expression profiles and downloadable data of 372 successful and 257 clinical trial targets across various tissues of 2,565 healthy individuals
  • 2,612 target combinations of 626 approved, 1,138 clinical trial and 278 research drug combinations, and 122 approved, 542 clinical trial and 25,333 research multi-target drugs (both are searchable via target, PFAM family, CATH family, KEGG pathway and species pairs respectively)
  • Additional 48 successful, 398 clinical trial and 66 research targets, 473 approved, 812 clinical trial and 1,120 experimental drugs
  • ICD-10-CM and ICD-9-CM codes for additional 482 targets and 262 drugs against 98 disease conditions

Statistics details of TTD Update 2018

Acknowledgement

Part of the datasets used for the biomarker analyses were obtained from dbGaP through its accession numbers such as phs000299.v2.p1.

Last Update by

15 Sep, 2017

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